Preclinical Drug Development

This volume discusses the broad and complicated realm of preclinical drug development. Topics discussed include pharmacokinetics, modeling and simulation, formulation and routes of administration, toxicity evaluations, the assessment of drug absorption and metabolism, and interspecies scaling. The authors also examine lead molecule selection and optimization via profiling and screening using in silico and in vitro toxicity evaluations. The book includes case studies on preclinical pharmacokinetic-pharmacodynamic modeling and simulation in drug development, a review of ICH preclinical guidelines, and experimental methods used to study membrane drug transport and metabolism.